The co-evolution between overseas emigrant entrepreneur networks and cluster networks in host countries is very important to gain the initiative in the going-out strategy. The emigrant entrepreneurs expect to grasp innovation resources from the cluster networks in host countries, as well as adopt isolation strategy to some extent for self-protection. This paper takes Chinese emigrants to Italy as a focal study, explains how the emigrant entrepreneur networks intertwine with cluster networks in host countries and analyzes changing rules between three characteristic distance variables, namely institutional distance, ability distance and cultural distance, and isolation state in the process of network co-evolution . The findings reveal that the interest games in the process of network co-evolution cause the existing of distance. Although distance generate isolation, the minimum level of distance is not equal to the minimized probability of isolation and culture distance can predict the probability of isolation antecedently. In turn, it highlights the decrease in three kinds of distance, especially culture distance, to weaken the motive for the implementation of protection-oriented isolation strategy and accelerate the co-evolution between overseas emigrant entrepreneur networks and cluster networks in host countries.