The theoretical tradition that concerns innovation and economy changes, which was originated from the classical economists and was carried forward by Schumpeter, is increasingly manifesting its strong vitality. The focus of innovation research also shifts from innovation itself to innovation agents and its economic, institutional and cultural environments, namely innovation system. Specifically speaking at meso-level of cities, creative city is not only concerned with the development of cultural creative industries and the solicitation of creative class, but also embodies the possibility of upgrading human well-being via the citizen-city-citizen accumulation cycle by cities as organisms that breed innovation. From the perspective of economic philosophy, the possibility lies in two paths at least: the first path is the further liberation of productivity, through going beyond instrumental reason step by step by creative thinking at culture level; the second path is the recurrence of human being through gradually replacing alienated labor by creative labor at institutional level.